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Title :有機リン系農薬の体内動態解析 -CE-MSによる代謝物分析法の開発と応用-
Title alternative :Toxicokinetics of organophosphorus insecticide -Development and application of the analytical method for the metabolites by CE-MS -
Authors :福家, 千昭
Issue Date :20-May-2010
Abstract :2007年度~2009年度科学研究費補助金(基盤研究(C))研究成果報告書
研究概要(英文) : We developed a determination method for the dialkylphosphates (DAPs), metabolites of organophosphate insecticides, using capillary electrophoresis / mass spectrometer (CE/MS) and applied this method to serum and urine collected from poisoned patients with organophosphate insecticide. The 7 DAPs were detected by CE-MS. In all of 29 caces of organophosphate insecticide poisoning, the expected DAPs were detected using this method. O,S-DMTP was also detected. The phosphate type and single or mix formulation of ingested organophosphate insecticide could be distinguished by determination of DAPs. There was a relation between DMP concentration in the serum and the degree of toxic symptoms.
Type Local :研究報告書
Publisher :福家千昭
URI :http://hdl.handle.net/20.500.12000/17850
Appears in Collections:Research Report (Faculty of Medicine)

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