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No.34 (1989/3) >

 
Title :A STUDY ON THE QUATERNARY STRUCTURE CHANGE OF HEMOGLOBIN I. INTERMEDIATE STRUCTURES IN O_2 LIGATION PROCESS
Authors :Arata, Yasuhide
Yara, Asao
Authors alternative :新田, 保秀
屋良, 朝夫
Issue Date :Mar-1989
Abstract :Conformational interaction at the interfaces between subunits are investigated on the basis of the atomic coordinates of human deoxy and human oxy Hbs. Hypothetical intermediate structures are used, each of which is obtained from the procedure where one or more subunits in deoxy Hb are replaced by the corresponding O_2-liganded subunits in oxy Hb using the method of superimposition of two sets of atomic coordinates. When either α or β subunit is substituted with the corresponding subunit in oxy Hb, serious steric hindrances are produced between α_1FG 4(92)Arg and β_2C 3(37)Trp or between α_1C 6(41)Thr and β_2FG 4(97)His, all of which belong to the allosteric core affected directly by ligand binding. These steric hindrances become more serious when both α_1(α_2) and β_2 (β_1) subunits are substituted. However, no steric hindrance can be seen between subunits when the subunits in oxy Hb are substituted with the corresponding subunits in deoxy Hb.
Type Local :紀要論文
ISSN :0386-5746
Publisher :琉球大学教育学部
URI :http://hdl.handle.net/20.500.12000/1873
Citation :琉球大学教育学部紀要 第一部・第二部 no.34 p.247 -257
Appears in Collections:No.34 (1989/3)

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