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No.22 (1976/09) >

 
Title :Study on the Reactions of Chromous Acetate with α, α'-Haloketo-steroids
Authors :Kuniyoshi, Masayuki
Authors alternative :国吉, 正之
Issue Date :Sep-1976
Abstract :5α-cholestan-4-one and 3β-acetoxy-5α-cholestan-6-one were prepared via several synthetic pathway from cholesterol. They were further converted into dibromo-derivatives; 3α, 5β-dibromo-4-oxo compound and 5α, 7α-dibromo-6-oxo compound respectively, by treatment with bromine in acetic acid containing a trace of 47% boron trifluoride ethyl ether at room temparatur. While chromous acetate was prepared from chromic chloride, zinc-amalgam and sodium acetate, and then it's reactivity for the a, α'-dibromoketo-steroids discribed above was investigated. The reaction of chromous acetate with the dibromoketo-compounds in acetic acid-chloroform (3:1) solution gave the reductive debrominated products, i.e., monobromoketo-compounds (about 20-25%) and its parent keto-compounds (about 8-10%).
Type Local :紀要論文
Publisher :琉球大学理工学部
URI :http://hdl.handle.net/20.500.12000/23669
Citation :琉球大学理工学部紀要. 理学編 = Bulletin of Science & Engineering Division, University of Ryukyus. Mathematics & natural sciences no.22 p.55 -61
Appears in Collections:No.22 (1976/09)

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