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Title :末梢神経急性圧迫障害に対する薬物療法の有効性に関する実験的研究
Title alternative :Experimental Studies of Drug Treatment Following Acute Nerve Compression Palsy
Authors :武内, 正典
Authors alternative :Takeuchi, Masanori
Issue Date :1994-3
Abstract :学位の種類(博士(医学)),学位授与機関(琉球大学),授与年月日(1994年3月18日),報告番号(乙第39号)
Steroids and nun-steroideal antiinflammatory drugs (NSAIDs) are often administered clinically for the treatment of nerve compression injury. The present study dealt with evaluation of the effect of steroids, NSAIDs (cyclooxygenase inhibitor) and Takeda AA-861 (lipoxygenase inhibitor) on the function, using the sciatic functional indx, histology and microcirculatiun of the rat sciatic nerves following compressin. The sciatic nerve of rats wrapped with a silicone tube with appropriate internal diameter caused a compression to the nerve. It was found that steroid therapy can prevent the functional impairment caused by compression. Silicone rubber injection into the artery of the rat sciatic nerve revealed the situation of vascular impairment. The edema occured in the epineurium was prevented by steroid administration. Following epineurectomy and application of silicone tube. this recovery was not recognized although steroid was given. NSAIDs (cyclooxygenase inhibitor) and/or Takeda AA-861 (lypoxigenase inhibitor) failed to have any benifical effect. Therefore it would be concluded that acute compression nerve palsy) is caused by ederna at epineurium and the utilization of steroid is effective to prevent dysfunction due to the extrapathway of arachidonic acid metabolism in inflammatory system.
Type Local :学位論文
Publisher :武内正典
URI :http://hdl.handle.net/20.500.12000/25399
Appears in Collections:Doctoral Dissertation (Graduate School of Medicine)

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