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No.57 (2000/9) >

Title :修正簡易精神症状検査 (3MS) と簡易トレール・メーキング検査 (BTMT) によるパーキンソン病患者の神経心理学的評価
Title alternative :The Neuropsychological Assessment of Parkinson's Disease using Modified Mini Mental State Examination (3MS) and Brief Trail Making Test (BTMT)
Authors :富永, 大介
Authors alternative :Tominaga, Daisuke
Issue Date :Sep-2000
Abstract :Parkinson's disease is a motor disorder which mainly shows tremor, muscle rigidity, hypokinesia and posture disorder. Recently Parkinson's disease has been said some kinds of cognitive dysfunctions similar to those of dementia. This study aims to examine the aspect of the cognitive function of Parkinson's disease patients under the following hypotheses. That is, whether Parkinson's disease shows the declined cognitive functions similar to patients who were dementia and the dysfunction of the frontal cortex. And does the chemical treatment of the Parkinson's disease affect their cognitive functions? Moreover, is there the degree of their severity related to their cognitive functions? Fifty-six outpatients who's ages ranged from 50 to 70 were given the Modified Mini Mental State Examination (3MS) which briefly tests the global cognitive function and the Brief Trial Making Test (BTMT) which is sensitive to the deficit of the frontal cortex function. The degree of their severity was assessed on the criterion of Hoehn & Yarh. Firstly, the total score of 3MS did not shown a significant cognitive disorder as a function of the their age compared with the matched control subjects. However, the total score of 3MS of the patients with the third and forth degree levels of severity of Parkinson's disease had significantly lower than those of the control subjects. Secondly, each of the four items of 3MS, first recall, writing, recall of four-legged animals and mental reversal, was shown the significance between patients with the third and forth level of their severity of Parkinson's disease and the control subjects. Also, each of the three items of 3MS, writing, copy two pentagons and recall of four-legged animals, was shown the significance between patients with first and second level and those of the third and forth level of their severity of Parkinson's disease. These results suggest that patients with Parkinson's disease should show the dysfunction of the frontal cortex. Thirdly, the total score of 3MS showed the slight correlation with dopamine drug but no correlation with anticholinergic drug, which is said affect memory. Whereas the combination dopamine drug with anticholinergic drug showed the positive correlation with the indices of BTMT. Hence, These results suggest that the lowed function of frontal cortex examining by the performance of BTMT might relate with these medical effects.
Type Local :紀要論文
ISSN :1345-3319
Publisher :琉球大学教育学部
URI :http://hdl.handle.net/20.500.12000/3288
Citation :琉球大学教育学部紀要 no.57 p.329 -341
Appears in Collections:No.57 (2000/9)

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