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The Science Bulletin of the Faculty of Agriculture. University of the Ryukyus >
No.49 (2002/12) >

 
Title :高コレステロール負荷ラットの血清および肝臓中の脂質濃度に及ぼす泡盛粕給与の影響
Title alternative :Effect of Awamori lees on serum and liver lipid concentrations in rats fed a high cholesterol diet
Authors :野原, 敏次
上地, 俊徳
小倉, 剛
川島, 由次
仲田, 正
田幸, 正邦
本郷, 富士彌
Authors alternative :Nohara, Toshitsugu
Uechi, Shuntoku
Ogura, Go
Kawashima, Yoshitsugu
Nakada, Tadashi
Tako, Masakuni
Hongo, Fujiya
Issue Date :1-Dec-2002
Abstract :未利用資源である泡盛粕を機能性食品あるいは家畜,ペットなどの動物用飼料源として広く活用するための基礎的知見を得るために,脂肪肝モデルラットに泡盛粕添加飼料を給与し,その発育,血液および肝臓脂質濃度に及ぼす影響を検討した.6週齢Wistar系雄性ラットに高コレステロール食を2週間給与し,脂肪肝モデルラットを作製した.次に,このラットを基本食を給与する対照群,基本色に泡盛粕をそれぞれ2.5,5および10%添加した飼料を与える3試験群,計4群を設定し,各飼料で30日間飼育した。この他に,44日の飼育期間中,基本食のみを給与した基本群も設定した。増体重で対照群と比較すると,泡盛粕2.5%および5%群において有意ではないが高い値を示した。しかし,10%群では逆に低い値を示した.摂食量は泡盛粕2.5%および5%添加群が対照群に比べて有意に高い値であった.血清脂質濃度において,いずれの測定項目にも有意な変化はなく,総コレステロールが泡盛粕5%添加群で対照群より若干低い値を示した.試験群の肝臓の色調については対照群のラット全てに明らかな白褐色化が観察されたのに対し,泡盛粕添加群では基本群と大差のない色調を呈する例が多かった.肝臓脂質濃度はバラツキが大きいため有意差は認められなかったが,泡盛粕添加群は対照群に比べてとても低い値を示した。これらの結果は,肝臓の組織学的検査で泡盛粕添加群に脂肪滴の数的減少および縮小化傾向が見られたことに一致していた.以上のことから,泡盛粕には高コレステロール負荷ラットの肝臓脂質濃度を低下させる作用を有していると示唆された.
The Awamori lees that was made by solid-liquid separation after distillation process is an unused resource. We investigated the effect of Awamori less on growth, serum and liver lipid concentrations to utilize as a functional food or feed stuff for domestic and pet animal. First, we made fatty liver model rats by feeding them a high cholesterol diet for 2 weeks. Second, these rats were divided into 4 groups : (i) control group given basal diet, (ii), (iii) and (iv) group given basal diet containing 2.5, 5 and 10% Awamori less, and each group was fed its respective diets for 30 days. Additionally, except the above groups, the standard group that was given only a basal diet during experimental period was set up. It was observed that body weight gain did not signficantly improve (p<0.05) when the diet containing 2.5% and 5% Awamori lees were given, however, 10% Awamori less group was unimproved. In feed consumption, the diet containing 2.5% and 5% Awamori lees was significantly improved (p<0.05). In serum lipid concentration, total cholesterol was reduced in 2.5% Awamori lees contained diet group, but all of measurement items were not significant values (p<0.05). The color tone of the control was white-brown, indicating a typical fatty liver, howeve, the group of Awamori lees contained diet was virtually the same color as the standard group. Liver lipid concentration was not significant (p<0.05) because these ovservations were so varied. The group that contained the Awamori lees diminished these concentrations as compared to the control group. These results agreed with numerical diminution and a scale reduction of adipose droplet to the group fed the diet containing Awamori less in the histological inspection of the liver. In conclusion, these results indicate that Awamori lees has the effect of decreasing liver lipid con-centration.
Type Local :紀要論文
ISSN :0370-4246
Publisher :琉球大学農学部
URI :http://hdl.handle.net/20.500.12000/3631
Citation :琉球大学農学部学術報告 = The Science Bulletin of the Faculty of Agriculture. University of the Ryukyus no.49 p.189 -197
Appears in Collections:No.49 (2002/12)

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