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No.24 (1977/12) >

Title :高温に対するマウスの生存時間の系統間比較と遺伝性(畜産学科)
Title alternative :Strain differences and inheritance of the survival time in mice under a high environment temperature(Department of Animal Husbandry)
Authors :新城, 明久
後藤, 豊彦
森田, 俊彦
Authors alternative :Shinjo, Akihisa
Goto, Toyohiko
Morita, Toshihiko
Issue Date :1-Dec-1977
Abstract :高温に対するマウスの生存時間の系統間比較を行うとともに耐暑性の遺伝を追究した。用いたマウスはAA, ICR, CF#1系およびヨナクニマウスであった。高温度曝露条件は, 鶏卵用孵卵器を用い, 温度40℃, 湿度約70%, 風速1.76m/秒とした。曝露は, 8週齢マウスを1ケージ当り3∿5匹入れ, 孵卵器の発生座に置き, 給水, 給餌しないで行った。その結果は以下のとうりである。1.ヨナクニマウスの体重はAA, ICRおよびCF#1系のヨウシュマウスの1/2以下であった。2.曝露下での平均生存時間は, 雄ではヨナクニマウスのみが他の3系統マウスより有意に長かった。雌ではICR系とAA系の間を除くすべての系統間に有意差がみられた。また雌は雄より生存時間が長く, 系統間差も拡大した。3.体重と生存時間との間に系統内および系統間でも負の相関関係が得られた。なお体重と生存時間との共分散分析でも生存時間の系統間差は雌雄とも有意であった。4.曝露中の1時間当りの体重減少率はヨナクニマウスが他の3系統マウスより有意に少なかった。5.F1マウスの生存時間は両親の平均値より長く, 雑種強勢が現われた。しかしF2マウスにおける雑種強勢の衰退は著しく, 感受性マウスに近づいた。以上のことからマウスの耐暑性に遺伝性があることが示唆された。
Inheritance of the heat tolerance in mice together with their strain differences in the survival time under a condition of a high environment temperature were investigated. In this study, the strains of AA, ICR and CF#1 mice (Mus musculus musculus) and Yonakuni mice (Mus molossinus yonakuni) at eight weeks of age were used. The mice, alloted three to five per cage, and fed no water and feed, were exposed to the following chicken incubater condition : temperature of 40℃, relative humidity of 70% and wind of 1.76m/second. 1. The average body weight of Yonakuni mice was less than one half of those of the AA, ICR and CF#1 mice at pre-expose. 2. The average survival durations of the AA, ICR, CF#1 and Yonakuni mice for male and female were 3.96,4.22,5.35,11.81 hours and 5.59,5.63,9.44,18.44 hours, respectively. As for the males, only Yonakuni mice showed a significantly longer survival time compared to other strains. Concerning with the females, on the other hand, all strain comparisons on the criterion were significant except that between ICR and AA strains. Compared to the males, the females were found to be more tolerable to the high environment temperature and they also showed larger strain differences. 3. Negative correlations within and among strains were observed in body weight and survival time. In addition, as for the analysis of covariance in body weight and survival time, strain differences of survival time for both sex were significant. 4. Decreased ratio of body weight/hr during the exposure of the mice to the high temperature was significantly smaller for Yonakuni mice compared to three other strains. 5. The survival time of F_1 mice was longer than the mid-parent value, showing a heterosis, nevertheless, the heterosis in F_2 mice was markedly decreased, while these animals having got close to the susceptible ICR mice. From these facts mentioned above, heat tolerance of mouse was found to be heritable.
Type Local :紀要論文
ISSN :0370-4246
Publisher :琉球大学農学部
URI :http://hdl.handle.net/20.500.12000/4252
Citation :琉球大学農学部学術報告 = The Science Bulletin of the Faculty of Agriculture. University of the Ryukyus no.24 p.465 -473
Appears in Collections:No.24 (1977/12)

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