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The Science Bulletin of the Faculty of Agriculture. University of the Ryukyus >
No.23 (1976/12) >

 
Title :R 因子保有菌に対するフラジオマイシン, パンフラン S およびフラゾリドンの効果(畜産学科)
Title alternative :Effect of fradiomycin, panfuran S and furazolidone on the R factors-carrying Escherichia coli (Department of Animal Husbandry)
Authors :金城, 俊夫
Authors alternative :Kinjo, Toshio
Issue Date :1-Dec-1976
Abstract :フラジオマイシン(FM), パンフランS(PFS), フラゾリドン(FZ)の3薬剤を用い, R^+大腸菌に対するR因子の除去効果および特異的殺菌効果があるか否かを検討し, 次の結果を得た。1.各家畜糞便由来R^+菌12株を用い, 延べ4,310箇の集落について, FM, PFS, FZのR因子除去効果を調べたところ, その効果は何れも低く, それぞれ0.80,0.75,0.98%で, これらの値はアクリフラビンのそれの約1/3以下であった。2.3薬剤がR^+菌に特異的に作用するか否かを, R^+菌108株, R^-菌193株についてMICの分布を指標に比較したところ, 全く差なく, 何れの菌群にも同程度の抗菌作用を示した。ただし, 対照の意味で用いたAB-PC等6剤に感受性のS菌193株については, 極めて高い感受性を示した。3.今回使用したFM, PFS, FZの3薬剤共, 特に実用面から家畜由来大腸菌のR因子除去剤あるいはR^+菌に特異的に作用する薬剤としての有効性は認められなかった。しかし, これら薬剤は家畜由来大腸菌に比較的高い抗菌作用を示した。
The eliminatory action of fradiomycin (FM), panfuran S (PFS) (=dihydroxymethyl furatrizine) and furazolidone (FZ) on R factors and also the specific action of these drugs on R factor-carrying (R^+) strains of E. coli was investigated. 1. A total of 12R^+ strains were treated with sublethal concentration of each drug for 18 hrs. Then, cells were streaked on the heart infusion agar plate and drug resistance of each colony was tested. Thus, a total of 4,310 colonies were investigsted. The frequencies of elimination were very low, such as 0.98% in FZ, 0.80% in FM and 0.75% in PFS. These values were rather low as compared with 2.92% in acriflavin and 1.27% in SDS which were obtained as control. 2. To investigate whether the specific action of the drugs on R^+ strains could be obtained, the average minimum inhibitory concentration (MIC) of 108 R^+ and 193 R^- strains was calculated and was compared. As control, MIC of 193 susceptible (S) strains for AB-PC, SM, TC, CP, KM and SA was also obtained. There were no differences between average MICs of the R^+ and R^- in any drugs, however, the average MIC of the S strains was significantly lower than those of the R^+ or R^- strains. From the results obtained, the author could not conclude that the 3 drugs, FM, PFS and FZ, have eliminatory action on R factors and also specific action on R^+ strains of E. coli.
Type Local :紀要論文
ISSN :0370-4246
Publisher :琉球大学農学部
URI :http://hdl.handle.net/20.500.12000/4308
Citation :琉球大学農学部学術報告 = The Science Bulletin of the Faculty of Agriculture. University of the Ryukyus no.23 p.303 -311
Appears in Collections:No.23 (1976/12)

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