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Title :Viral antigens detectable in CSF exosomes from patients with retrovirus associated neurologic disease : functional role of exosomes.
Authors :Anderson, Monique R.
Pleet, Michelle L.
Enose-Akahata, Yoshimi
Erickson, James
Monaco, Maria Chiara
Akpamagbo, Yao
Velluchi, Ashley
Tanaka, Yuetsu
Azodi, Shila
Lepene, Ben
Jones, Jennifer
Kashanchi, Fatah
Jacobson, Steven
Issue Date :27-Aug-2018
Abstract :HTLV-1 infects over 20 million people worldwide and causes a progressive neuroinflammatory disorder in a subset of infected individuals called HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). The detection of HTLV-1 specific T cells in the cerebrospinal fluid (CSF) suggests this disease is immunopathologically mediated and that it may be driven by viral antigens. Exosomes are microvesicles originating from the endosomal compartment that are shed into the extracellular space by various cell types. It is now understood that several viruses take advantage of this mode of intercellular communication for packaging of viral components as well. We sought to understand if this is the case in HTLV-1 infection, and specifically if HTLV-1 proteins can be found in the CSF of HAM/TSP patients where we know free virus is absent, and furthermore, if exosomes containing HTLV-1 Tax have functional consequences.
URL :https://doi.org/10.1186/s40169-018-0204-7
Type Local :雑誌掲載論文
ISSN :2001-1326
Publisher :SpringerOpen
Springer Berlin Heidelberg
URI :http://hdl.handle.net/20.500.12000/45205
Citation :Clinical and Translational Medicine Vol.7 no.24
Appears in Collections:Peer-reviewed Journal Articles (Faculty of Medicine)

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