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Title :Immunophenotypic characterization of CSF B cells in virus-associated neuroinflammatory diseases
Authors :Enose-Akahata, Yoshimi
Azodi, Shila
Smith, Bryan R.
Billioux, Bridgette Jeanne
Vellucci, Ashley
Ngouth, Nyater
Tanaka, Yuetsu
Ohayon, Joan
Cortese, Irene
Nath, Avindra
Jacobson, Steven
Issue Date :30-Apr-2018
Abstract :Intrathecal antibody synthesis is a well-documented phenomenon in infectious neurological diseases as well as in demyelinating diseases, but little is known about the role of B cells in the central nervous systems. We examined B cell and T cell immunophenotypes in CSF of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) compared to healthy normal donors and subjects with the other chronic virus infection and/or neuroinflammatory diseases including HIV infection, multiple sclerosis (MS) and progressive multifocal leukoencephalopathy. Antibody secreting B cells (ASCs) were elevated in HAM/TSP patients, which was significantly correlated with intrathecal HTLV-1-specific antibody responses. High frequency of ASCs was also detected in patients with relapsing-remitting multiple sclerosis (RRMS). While RRMS patients showed significant correlations between ASCs and memory follicular helper CD4+ T cells, CD4+CD25+ T cells were elevated in HAM/TSP patients, which were significantly correlated with ASCs and HTLV-1 proviral load. These results highlight the importance of the B cell compartment and the associated inflammatory milieu in HAM/TSP patients where virus-specific antibody production may be required to control viral persistence and/or may be associated with disease development.
URL :https://doi.org/10.1371/journal.ppat.1007042
Type Local :雑誌掲載論文
ISSN :1553-7374
Publisher :Public Library of Science
URI :http://hdl.handle.net/20.500.12000/45646
Citation :PLOS Pathogens Vol.14 no.4
Appears in Collections:Peer-reviewed Journal Articles (Faculty of Medicine)

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