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Title :Production of a high level of specific IgG4 antibody associated with resistance to albendazole treatment in HLA-DRBI*0901-positive patients with strongyloidiasis
Authors :Satoh, Masao
Toma, Hiromu
Sato, Yoshiya
Kikuchi, Mihoko
Takara, Masahiro
Shiroma, Yoshiyuki
Kiyuna, Susumu
Hirayama, Kenji
Issue Date :Oct-1999
Abstract :Strongyloidiasis, a human intestinal infection with Strongyloides stercoralis, is difficult to treat with drugs. The factors influencing this phenomenon remain unclear. To determine the host factors involved in response to treatment, 46 patients with strongyloidiasis were treated with albendazole, followed-up for 1 year, and separated into two groups: cured and non-cured, Serum levels of specific IgA, IgE, IgG, IgG1, and IgC4 antibodies were estimated using S. stercoralis antigen. Significantly higher titers of IgG4 antibody were observed in the non-cured group than in the cured group (P = 0.016). A total of 88 patients were typed for HLA-DRB1 alleles and analyzed for serum levels of antibody. The S. stercoralis-specific IgG4 antibody titers were significantly higher in the HLA-DRB1*0901-positive group than in the negative group (corrected P = 0.044). These results suggest that HLA-DRB1*0901 is a possible genetic marker for resistance to treatment of S. stercoralis that is associated with elevation of S. stercoralis-specific IgG4 antibody titer.
URL :https://doi.org/10.4269/ajtmh.1999.61.668
Type Local :雑誌掲載論文
ISSN :0002-9637
1476-1645
Publisher :The American Society of Tropical Medicine and Hygiene
URI :http://hdl.handle.net/20.500.12000/45869
Citation :The American Journal of Tropical Medicine and Hygiene Vol.61 no.4 p.668 -671
Appears in Collections:Peer-reviewed Journal Articles (Faculty of Medicine)

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