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Title :Vesicovaginal/rectovaginal fistula formation and outcome of Stage IVA carcinoma of the cervix treated with radiotherapy
Authors :Kinjyo, Y.
Kudaka, W.
Toita, T.
Nakamoto, T.
Nagai, Y.
Maemoto, H.
Hashimoto, S.
Ariga, T.
Aoki, Y.
Issue Date :10-Dec-2017
Abstract :Purpose: To review the morbidity and mortality of Stage IVA cervical cancer, with a particular focus on the incidence of fistulae. Materials and Methods: The authors retrospectively analyzed 30 patients with Stage IVA cervical cancer, treated with whole pelvic-external beam radiotherapy (WP-EBRT) and high-dose-rate intracavitary brachytherapy (HDR-ICBT). Results: Seven patients presented with vesicovaginal fistula at the time of cancer diagnosis and six developed a fistula during or after radiotherapy (RT). Fistula was diagnosed 0-41 months after cancer diagnosis. The patients with fistulae had a median survival of 32 months. Six patients are alive, four of whom have no evidence of recurrence, while two have persistent disease. The five-year overall survival (OS) was 14.9% in the patients with fistula and was 39.4% in the total series. On multivariate analysis, RT without HDR-ICBT was an independent prognostic factor. Conclusion: High rates of vesicovaginal fistulae were observed in Stage IVA cervical cancer. Interventions for vesicovaginal fistula to improve quality of life are very important.
URL :https://ejgo.imrpress.com/EN/10.12892/ejgo3701.2017
Type Local :雑誌掲載論文
ISSN :0392-2936
Publisher :IMR PRESS
URI :http://hdl.handle.net/20.500.12000/45889
Citation :European Journal of Gynaecological Oncology Vol.38 no.6 p.938 -942
Appears in Collections:Peer-reviewed Journal Articles (Faculty of Medicine)

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