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Title :Concurrent weekly cisplatin versus triweekly cisplatin with radiotherapy for locally advanced squamous-cell carcinoma of the cervix : a retrospective analysis from a single institution
Authors :Kinjyo, Yoshino
Nagai, Yutaka
Toita, Takafumi
Kudaka, Wataru
Ariga, Takuro
Shimoji, Yuko
Nakasone, Tadaharu
Taira, Yusuke
Arakaki, Yoshihisa
Nakamoto, Tomoko
Wakayama, Akihiko
Ooyama, Takuma
Maemoto, Hitoshi
Heianna, Joichi
Aoki, Yoichi
Issue Date :2017
Abstract :Objective:To compare patients with cervical cancer who were primarily treated with concurrent chemoradiotherapy (CCRT) using 20 mg m^<-2> CDDP for 5 days every 3 weeks with weekly regimens of 40 mg m^<-2>. Methods:We retrospectively analyzed 185 patients with Stage IB-IVA squamous-cell carcinoma of the cervix who were treated with CCRT between 2005 and 2013 at our hospital. The CCRT regimen consisted of cisplatin (CDDP) at 20 mg m^<-2> for 5 days every 3 weeks or 40 mg m^<-2> weekly, administered concomitantly with RT. Results:The median age was 50 years (range: 22-70 years) in the triweekly group and was 50.5 years (range: 28-70 years) in the weekly group. The 5-year overall survival rate in the triweekly and weekly groups were 82.0% and 83.3%, respectively (p = 0.851); their disease-free survival rate was 79.6% and 78.1%, respectively (p = 0.672). In the triweekly group, 56 patients (50.9%) had grade 3/4 leukopenia, which was significantly higher than that of 11 patients (15%) in the weekly group (p < 0.0001). Conclusion:The weekly CDDP regimen for CCRT seems better in patients with International Federation of Gynecology and Obstetrics Stages IB-IVA squamous-cell carcinoma of the cervix. Advances in knowledge: The weekly CDDP regimen for CCRT seems better in patients with International Federation of Gynecology and Obstetrics Stages IB-IVA squamous-cell carcinoma of the cervix.
URL :https://doi.org/10.1259/bjr.20170241
Type Local :雑誌掲載論文
ISSN :0007-1285
1748-880X
Publisher :The British Institute of Radiology
URI :http://hdl.handle.net/20.500.12000/46027
Citation :The British Journal of Radiology Vol.90 no.1076
Appears in Collections:Peer-reviewed Journal Articles (Faculty of Medicine)

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