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Title :Long-term Treatment of Teicoplanin for Methicillin-resistant Staphylococcus aureus Sternal Osteomyelitis with Renal Impairment : A Case of High Teicoplanin Trough Levels Maintained by Therapeutic Drug Monitoring
Authors :Shiohira, Hideo
Nakamatsu, Masashi
Kise, Yuya
Higa, Futoshi
Tateyama, Masao
Hokama, Nobuo
Kuniyoshi, Yukio
Ueda, Shinichiro
Nakamura, Katsunori
Fujita, Jiro
Issue Date :1-Sep-2016
Abstract :Teicoplanin, a glycopeptide antibiotic for methicillin-resistant Staphylococcus aureus, is recommended for therapeutic drug monitoring during treatment. Maintaining a high trough range of teicoplanin is also recommended for severe infectious disease. However, the optimal dose and interval of treatment for severe renal impairment is unknown. We report a 79-year-old man who received long-term teicoplanin treatment for methicillin-resistant Staphylococcus aureus bacteremia due to postoperative sternal osteomyelitis with renal impairment. Plasma teicoplanin trough levels were maintained at a high range (20-30 μg/mL). Although the patient required long-term teicoplanin treatment, a further decline in renal function was not observed, and blood culture remained negative after the start of treatment. Teicoplanin treatment that is maintained at a high trough level by therapeutic drug monitoring might be beneficial for severe methicillin-resistant Staphylococcus aureus infection accompanied by renal impairment.
URL :https://doi.org/10.1248/yakushi.15-00296
Type Local :雑誌掲載論文
ISSN :1347-5231
Publisher :The Pharmaceutical Society of Japan
URI :http://hdl.handle.net/20.500.12000/46425
Citation :YAKUGAKU ZASSHI Vol.136 no.9 p.1313 -1317
Appears in Collections:Peer-reviewed Journal Articles (Faculty of Medicine)

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