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Title :Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum
Authors :Takayama, Chitoshi
Inoue, Yoshiro
Issue Date :Feb-2007
Abstract :Developmental shift in GABA actions from depolarization to hyperpolarization occurs as a result of decreasing the intracellular Cl--concentration regulated by K+-Cl- co-transporter 2 (KCC2). To clarify the time-course of the developmental shift on the Purkinje cells, we examined KCC2-localization in the embryonic mouse cerebellum. The KCC2 was first detected within the Purkinje cells in the Purkinje cell layer of the hemisphere at embryonic day 15 (E15) and the vermis at E17, but the ventricular and intermediate zones were negative. These results suggest that GABA might become inhibitory on the Purkinje cells after their settling in the Purkinje cell layer.
URL :https://doi.org/10.1016/j.neures.2006.10.016
Type Local :雑誌掲載論文
ISSN :0168-0102
Publisher :Elsevier
URI :http://hdl.handle.net/20.500.12000/46549
Citation :Neuroscience Research Vol.57 no.2 p.322 -325
Appears in Collections:Peer-reviewed Journal Articles (Faculty of Medicine)

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