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Title :A pilot assessment of xanthine oxidase activity in plasma from patients with hematological malignancies using a highly sensitive assay
Authors :Hokama, Noboru
Authors alternative :外間, 登
Issue Date :29-Jul-2019
Abstract :Xanthine oxidase (XO) is a rate limiting enzyme for production of uric acid. The activity of XO in plasma is reported to elevate in patients with familial hypercholesterolaemia and cardiovascular diseases. Such an increase in plasma XO activity was also demonstrated in patients with a variety of cancers. However, there have been few reports evaluating the plasma XO activity in patients with hematological malignancies during course of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and chemotherapies. We explored the relationship between plasma XO activity and clinical symptoms/biochemical parameters in 10 patients with hematological malignancies. The XO activity was measured by a highsensitivity fluorescence technique. Plasma XO activity in hematological malignancies before chemotherapy was not elevated compared to healthy subjects. In patients receiving allo-HSCT, no apparent increase in plasma XO activity was observed at the appearance of graft-versus-host disease (GVHD). Noticeably, however, the value of plasma XO activity was closely associated with that of serum level of liver transaminases in the course of allo-HSCT and chemotherapies. To our knowledge, the present study is the first to investigate consecutively the value in plasma XO activity in patients with hematological malignancies. Despite small numbers analyzed, value of plasma XO activity was tightly associated with that of serum level of liver transaminases in the course of allo-HSCT and chemotherapies, suggesting that the value may reflect liver damage related with a variety of therapeutic interventions.
URL :https://doi.org/10.1002/hon.2659
Type Local :学位論文
ISSN :0278-0232
1099-1069
Publisher :University of the Ryukyus
URI :http://hdl.handle.net/20.500.12000/46669
Grant id :18001医研第506号
Date of granted :2020-03-24
Degree name :博士(医学)
Grantor :琉球大学
Citation :Hematological Oncology Vol.37 no.4 p.527 -530
Appears in Collections:Doctoral Dissertation (Graduate School of Medicine)

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