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Title :Adipose tissue-derived mesenchymal stem cells ameliorate bone marrow aplasia related with graft-versus-host disease in experimental murine models
Authors :Nishi, Yukiko
Authors alternative :西, 由希子
Issue Date :Aug-2019
Abstract :Graft-versus-host disease (GVHD) constitutes the most frequent complications after the allogeneic hematopoietic stem cell transplantation for a variety of hematological malignancies. In the present study, we explored the prophylactic potential of adipose tissue-derived mesenchymal stem cells (AD-MSCs) in controlling GVHD in murine models with a special focus on bone marrow aplasia related with acute GVHD. The CB6F1 mice were induced GVHD by the injection intravenously of C57BL/6 (B6-Ly-5.1) splenocytes without conditioning irradiation or chemotherapy. AD-MSCs from C3H mice were injected intravenously via tail veins. GVHD was assessed using flowcytometry analysis of peripheral blood cells and histopathologic analysis of target organs. Histopathological analyses revealed that AD-MSCs markedly suppressed the infiltration of lymphocytes into liver as well as the aplasia in bone marrow. This study is the first to clarify the effectiveness of AD-MSCs against bone marrow aplasia in GVHD, supporting a rationale of AD-MSCs for ameliorating bone marrow suppression and infectivity after allo-HSCT in human clinics.
URL :https://doi.org/10.1016/j.trim.2019.03.004
Type Local :学位論文
ISSN :0966-3274
Publisher :University of the Ryukyus
URI :http://hdl.handle.net/20.500.12000/46670
Grant id :18001医研第498号
Date of granted :2019-09-25
Degree name :博士(医学)
Grantor :琉球大学
Citation :Transplant Immunology Vol.55
Appears in Collections:Doctoral Dissertation (Graduate School of Medicine)

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