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Title | : | A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes |
Authors | : | Taira, Makiko Imamura, Minako Takahashi, Atsushi Kamatani, Yoichiro Yamauchi, Toshimasa Araki, Shin-ichi Tanaka, Nobue van Zuydam, Natalie R. Ahlqvist, Emma Toyoda, Masao Umezono, Tomoya Kawai, Koichi Imanishi, Masahito Watada, Hirotaka Suzuki, Daisuke Maegawa, Hiroshi Babazono, Tetsuya Kaku, Kohei Kawamori, Ryuzo Groop, Leif C. McCarth, Mark, I Kadowaki, Takashi Maeda, Shiro The SUMMIT Consortium |
Issue Date | : | 19-Dec-2018 |
Abstract | : | To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with type 2 diabetes. We analyzed the association of 5,768,242 single nucleotide polymorphisms (SNPs) in Japanese patients with type 2 diabetes, 2,380 nephropathy cases and 5,234 controls. We further performed GWAS for diabetic nephropathy using independent Japanese patients with type 2 diabetes, 429 cases and 358 controls and the results of these two GWAS were combined with an inverse variance meta-analysis (stage-1), followed by a de novo genotyping for the candidate SNP loci (p < 1.0 x 10^<-4>) in an independent case-control study (Stage-2; 1,213 cases and 1,298 controls). After integrating stage-1 and stage-2 data, we identified one SNP locus, significantly associated with diabetic nephropathy; rs56094641 in FTO, P = 7.74 x 10^<-10>. We further examined the association of rs56094641 with diabetic nephropathy in independent Japanese patients with type 2 diabetes (902 cases and 1,221 controls), and found that the association of this locus with diabetic nephropathy remained significant after integrating all association data (P = 7.62 x 10^<-10>). We have identified FTO locus as a novel locus for conferring susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes. |
URL | : | https://doi.org/10.1371/journal.pone.0208654 |
Type Local | : | 雑誌掲載論文 |
ISSN | : | 1932-6203 |
Publisher | : | Public Library of Science |
URI | : | http://hdl.handle.net/20.500.12000/46886 |
Citation | : | PLOS ONE Vol.13 no.12 |
Appears in Collections | : | Peer-reviewed Journal Articles (Faculty of Medicine)
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