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|Title ||:||A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes|
|Authors ||:||Taira, Makiko|
van Zuydam, Natalie R.
Groop, Leif C.
McCarth, Mark, I
The SUMMIT Consortium
|Issue Date ||:||19-Dec-2018 |
|Abstract ||:||To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with type 2 diabetes. We analyzed the association of 5,768,242 single nucleotide polymorphisms (SNPs) in Japanese patients with type 2 diabetes, 2,380 nephropathy cases and 5,234 controls. We further performed GWAS for diabetic nephropathy using independent Japanese patients with type 2 diabetes, 429 cases and 358 controls and the results of these two GWAS were combined with an inverse variance meta-analysis (stage-1), followed by a de novo genotyping for the candidate SNP loci (p < 1.0 x 10^<-4>) in an independent case-control study (Stage-2; 1,213 cases and 1,298 controls). After integrating stage-1 and stage-2 data, we identified one SNP locus, significantly associated with diabetic nephropathy; rs56094641 in FTO, P = 7.74 x 10^<-10>. We further examined the association of rs56094641 with diabetic nephropathy in independent Japanese patients with type 2 diabetes (902 cases and 1,221 controls), and found that the association of this locus with diabetic nephropathy remained significant after integrating all association data (P = 7.62 x 10^<-10>). We have identified FTO locus as a novel locus for conferring susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.|
|Type Local ||:||雑誌掲載論文|
|Publisher ||:||Public Library of Science|
|Citation ||:||PLOS ONE Vol.13 no.12 |
|Appears in Collections||:||Peer-reviewed Journal Articles (Faculty of Medicine)|
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