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Title :Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes
Authors :Imamura, Minako
Takahashi, Atsushi
Yamauchi, Toshimasa
Hara, Kazuo
Yasuda, Kazuki
Grarup, Niels
Zhao, Wei
Wang, Xu
Huerta-Chagoya, Alicia
Hu, Cheng
Moon, Sanghoon
Long, Jirong
Kwak, Soo Heon
Rasheed, Asif
Saxena, Richa
Ma, Ronald C. W.
Okada, Yukinori
Iwata, Minoru
Hosoe, Jun
Shojima, Nobuhiro
Iwasaki, Minaka
Fujita, Hayato
Suzuki, Ken
Danesh, John
Jorgensen, Torben
Jorgensen, Marit E.
Witte, Daniel R.
Brandslund, Ivan
Christensen, Cramer
Hansen, Torben
Mercader, Josep M.
Flannick, Jason
Moreno-Macias, Hortensia
Burtt, Noel P.
Zhang, Rong
Kim, Young Jin
Zheng, Wei
Singh, Jai Rup
Tam, Claudia H. T.
Hirose, Hiroshi
Maegawa, Hiroshi
Ito, Chikako
Kaku, Kohei
Watada, Hirotaka
Tanaka, Yasushi
Tobe, Kazuyuki
Kawamori, Ryuzo
Kubo, Michiaki
Cho, Yoon Shin
Chan, Juliana C. N.
Sanghera, Dharambir
Frossard, Philippe
Park, Kyong Soo
Shu, Xiao-Ou
Kim, Bong-Jo
Florez, Jose C.
Tusie-Luna, Teresa
Jia, Weiping
Tai, E. Shyong
Pedersen, Oluf
Saleheen, Danish
Maeda, Shiro
Kadowaki, Takashi
Issue Date :28-Jan-2016
Abstract :Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 x 10^<-8>), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.
URL :https://doi.org/10.1038/ncomms10531
Type Local :雑誌掲載論文
ISSN :2041-1723
Publisher :Springer Nature
URI :http://hdl.handle.net/20.500.12000/46887
Citation :Nature Communications Vol.7
Appears in Collections:Peer-reviewed Journal Articles (Faculty of Medicine)

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