Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes: University of the Ryukyus Repository


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Title	:	Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes
Authors	:	Imamura, Minako Takahashi, Atsushi Yamauchi, Toshimasa Hara, Kazuo Yasuda, Kazuki Grarup, Niels Zhao, Wei Wang, Xu Huerta-Chagoya, Alicia Hu, Cheng Moon, Sanghoon Long, Jirong Kwak, Soo Heon Rasheed, Asif Saxena, Richa Ma, Ronald C. W. Okada, Yukinori Iwata, Minoru Hosoe, Jun Shojima, Nobuhiro Iwasaki, Minaka Fujita, Hayato Suzuki, Ken Danesh, John Jorgensen, Torben Jorgensen, Marit E. Witte, Daniel R. Brandslund, Ivan Christensen, Cramer Hansen, Torben Mercader, Josep M. Flannick, Jason Moreno-Macias, Hortensia Burtt, Noel P. Zhang, Rong Kim, Young Jin Zheng, Wei Singh, Jai Rup Tam, Claudia H. T. Hirose, Hiroshi Maegawa, Hiroshi Ito, Chikako Kaku, Kohei Watada, Hirotaka Tanaka, Yasushi Tobe, Kazuyuki Kawamori, Ryuzo Kubo, Michiaki Cho, Yoon Shin Chan, Juliana C. N. Sanghera, Dharambir Frossard, Philippe Park, Kyong Soo Shu, Xiao-Ou Kim, Bong-Jo Florez, Jose C. Tusie-Luna, Teresa Jia, Weiping Tai, E. Shyong Pedersen, Oluf Saleheen, Danish Maeda, Shiro Kadowaki, Takashi
Issue Date	:	28-Jan-2016
Abstract	:	Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 x 10^<-8>), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.
URL	:	https://doi.org/10.1038/ncomms10531
Type Local	:	雑誌掲載論文
ISSN	:	2041-1723
Publisher	:	Springer Nature
URI	:	http://hdl.handle.net/20.500.12000/46887
Citation	:	Nature Communications Vol.7
Appears in Collections	:	Peer-reviewed Journal Articles (Faculty of Medicine)

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