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Title :An Okhotsk adult female human skeleton (11th/12th century AD) with possible SAPHO syndrome from Hamanaka 2 site, Rebun Island, northern Japan
Authors :Okamoto, Yuka
Ishida, Hajime
Kimura, Ryosuke
Sato, Takehiro
Tsuchiya, Nanae
Murayama, Sadayuki
Fukase, Hitoshi
Nagaoka, Tomohito
Adachi, Noboru
Yoneda, Minoru
Andrzej, Weber
Kato, Hirofumi
Issue Date :2016
Abstract :We present the oldest human skeletal case yet identified with possible SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis), a chronic disease involving the skin, bone, and joints. A human skeleton with a severe pathological condition was recovered from a shell mound of the prehistoric Okhotsk culture at the Hamanaka 2 site, Rebun Island, Hokkaido, Japan in 2013. Morphological and Amelogenin gene analyses determined the sex as female, and the age at time of death was estimated to be in the forties using analysis of the auricular surface of the ilium. The stable isotope ratios of this individual (NAT002) and other Hamanaka 2 samples indicated a heavy dependence on marine mammals and fish for dietary protein intake. Radiocarbon age on collagen from the bone of NAT002 was 1689 ± 20 BP, or 1060–1155 (68.2%) calAD. Macroscopic and computed tomography (CT) findings indicated diffuse hyperostosis in the axial and appendicular skeleton, including the mandible, vertebrae, clavicles, sternum, scapulae, humeri, radii, ulnae, and ilium, caused by osteitis and synovitis. The bilateral clavicles were most affected, in which CT imaging revealed irregular cortical thickening, termed ‘grotesque periostitis.’ The case was diagnosed as most likely having SAPHO syndrome, although dermatological findings could not be detected. Although SAPHO syndrome is a fairly new concept in autoimmune diseases, this case suggests the syndrome originated much earlier in human history.
URL :https://doi.org/10.1537/ase.160608
Type Local :雑誌掲載論文
ISSN :1348-8570
Publisher :The Anthropological Society of Nippon
URI :http://hdl.handle.net/20.500.12000/46970
Citation :Anthropological Science Vol.124 no.2 p.107 -115
Appears in Collections:Peer-reviewed Journal Articles (Faculty of Medicine)

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