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Title :Association of ADRB2 polymorphism with triglyceride levels in Tongans
Authors :Naka, Izumi
Ohashi, Jun
Kimura, Ryosuke
Inaoka, Tsukasa
Matsumura, Yasuhiro
Issue Date :23-Jul-2013
Abstract :Background:Our previous study demonstrated that the A-allele of the single nucleotide polymorphism (SNP) rs34623097 located in the upstream region of the β2 adrenergic receptor gene (ADRB2) is significantly associated with risk for obesity in Oceanic populations. Methods:To investigate whether the ADRB2 polymorphisms explain part of the individual differences in lipid mobilization, energy expenditure and glycogen breakdown, the associations of 10 ADRB2 SNPs with total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride levels were examined in 128 adults in Tonga. Results:A multiple linear regression analysis adjusted for age, sex, and body mass index revealed that rs34623097 was significantly associated with triglyceride levels (P-value = 0.037). A copy of the rs34623097-A allele increased serum triglyceride levels by 70.1 mg/dL (0.791 mmol/L). None of the ADRB2 SNPs showed a significant association with total-cholesterol, high-density lipoprotein cholesterol, or low-density lipoprotein cholesterol. Conclusions:In a Tongan population, a SNP located in the upstream region of ADRB2 is associated with triglyceride levels independent of body mass index.
URL :https://doi.org/10.1186/1476-511X-12-110
Type Local :雑誌掲載論文
ISSN :1476-511X
Publisher :BioMed Central
URI :http://hdl.handle.net/20.500.12000/46973
Citation :Lipids in Health and Disease Vol.12
Appears in Collections:Peer-reviewed Journal Articles (Faculty of Medicine)

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