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Title :Intestinal helminth infections in HIV-infected patients in Savannakhet after establishment of an HIV registration network in Lao People’s Democratic Republic
Authors :Kaneshiro, Yukako
Sourinphoumy, Khamphang
Imaizumi, Naoki
Rasaphon, Mangkhalar
Kuba-Miyara, Megumi
Sakihama, Shugo
Guerrero, Carmina Louise Hugo
Nhativong, Ketsaphone
Nonaka, Daisuke
Pongvongsa, Tiengkham
Kobayashi, Jun
Kounnavong, Sengchanh
Fukushima, Takuya
Issue Date :11-Feb-2019
Abstract :Background: In Lao People’s Democratic Republic (PDR), which borders China, Vietnam, Cambodia, Thailand, and Myanmar, the number of HIV-infected patients has increased in recent years. HIV-infected patients diagnosed in Lao PDR are enrolled in a registration network and receive antiretroviral therapy (ART) covered by governmental financial support. Based on the registration network, we investigated intestinal helminth infections and coinfection with HTLV-1 in HIV-infected patients treated with an early intervention using ART in Lao PDR. Methods: This cross-sectional study of all 252 HIV-infected patients at Savannakhet Provincial Hospital, located in the southern part of Lao PDR, was conducted between February and March 2018. Socioepidemiological information and clinical information were collected from a registration network database and by questionnaire administered to participants. Microscopic examination of intestinal helminth infections in stool samples and particle agglutination for anti-HTLV-1 antibody in plasma were performed. Results: The median age of all 252 participants was 39 years old (range, 18–59). Based on the registration network database, there were 156 (61.9%) HIV-infected patients with a CD4-positive cell count ≥ 200 cells/μL and 146 (57.9%) with an HIV viral load < 250 copies/mL. Among 212 stool samples, 75 (35.4%) were found to contain one or more intestinal helminth species, including Opisthorchis viverrini (16.5%), Strongyloides stercoralis (10.8%), hookworm (10.4%), and Taenia saginata (3.3%). This rate of intestinal helminth infections was lower than that of a previous report conducted before the establishment of the registration network for HIV-infected patients in Lao PDR. There was no significant association between intestinal helminth infections and a lower CD4-positive T cell count or higher HIV viral load. HIV-infected patients with anti-HTLV-1 antibody positivity were not found in this cohort. Conclusion: The registration network and an early intervention using ART may provide good medical care and improve the clinical course of HIV-infected patients in Lao PDR. However, the incidence of intestinal helminth infections remains high at 35.4%. The development of a specific medical care system for helminth infection for HIV-infected patients is necessary.
URL :https://doi.org/10.1186/s41182-019-0142-0
Type Local :雑誌掲載論文
ISSN :1349-4147
Publisher :Springer Nature
URI :http://hdl.handle.net/20.500.12000/47230
Citation :Tropical Medicine and Health Vol.47
Appears in Collections:Peer-reviewed Journal Articles (Faculty of Medicine)

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