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Title :Recurrence of Psoriasis Vulgaris Accompanied by Treatment with C-C Chemokine Receptor Type 4 (CCR4) Antibody (Mogamulizumab) Therapies in a Patient with Adult T cell Leukemia/ Lymphoma : Insight into Autoinflammatory Diseases
Authors :Morichika, Kazuho
Tomoyose, Takeaki
Hanashiro, Taeko
Shimabukuro, Natsuki
Tamaki, Keita
Tedokon, Iori
Nishi, Yukiko
Nakachi, Sawako
Karube, Ken-nosuke
Fukushima, Takuya
Katoh, Takeharu
Ohshima, Koichi
Masuzaki, Hiroaki
Issue Date :2016
Abstract :Adult T cell leukemia / lymphoma (ATL) is one of the most aggressive hematological malignancies caused by human T-lymphotropic virus type-I (HTLV-1). Mogamulizumab is a new defucosylated humanized monoclonal antibody agent which targets C-C chemokine receptor type 4 (CCR4) expressed occasionally on the surface of ATL cells. However, adverse events such as drug eruptions have also been highlighted, at least in part, via the dysfunction of regulatory T cells (Tregs). We herein report a pronounced recurrence of systemic psoriasis vulgaris accompanied by the treatment of mogamulizumab in a patient with ATL. Pathological examinations may suggest a mechanistic link between the recurrence of autoinflammatory diseases and anti-CCR4 antibody therapies.
URL :https://doi.org/10.2169/internalmedicine.55.5997
Type Local :雑誌掲載論文
ISSN :1349-7235
Publisher :The Japanese Society of Internal Medicine
URI :http://hdl.handle.net/20.500.12000/47234
Citation :Internal Medicine Vol.55 no.10 p.1345 -1349
Appears in Collections:Peer-reviewed Journal Articles (Faculty of Medicine)

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