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Title :Effectiveness of Subcutaneous Growth Hormone in HIV-1 Patients with Moderate to Severe Facial Lipoatrophy
Authors :Honda, Miwako
Yogi, Akira
Ishizuka, Naoki
Genka, Ikumi
Gatanaga, Hiroyuki
Teruya, Katsuji
Tachikawa, Natsuo
Kikuchi, Yoshimi
Oka, Shinichi
Issue Date :2007
Abstract :Objective: To evaluate effect of recombinant human growth hormone (rhGH) among HIV-infected adults with moderate to severe facial lipoatrophy as a side effect of long-term antiretroviral treatment. Design: A prospective open-label study Methods: Twenty-five HIV-1 patients with moderate to severe facial lipoatrophy who had been on antiretroviral treatment for more than 18 months were enrolled. rhGH (5 mg) was given every other day for 6 months. After treatment was completed, the participants were followed up for 6 months. Facial lipoatrophy was evaluated by computed tomography at months 0, 3, 6 and 12. Results: Nearly all participants (24 of 25) completed the study. The sum of bilateral soft tissue thickness at the level of zygomatics at months 0, 3, 6, 12 were 7.23, 8.59, 8.35, 8.60 mm, respectively. There was significant improvement from baseline in month 3 (p=0.009) and month 12 (p=0.021). In the 6 months of follow-up, the soft tissue showed no significant decrease. Several side effects including diarrhea, arthralgia, myalgia, mastalgia and hand numbness were seen, which were self-limited and transient. Conclusion: rhGH is effective and relatively safe for moderate to severe facial lipoatrophy. Its effect was sustained at least for 6 months after the cessation of rhGH.
URL :https://doi.org/10.2169/internalmedicine.46.6122
Type Local :雑誌掲載論文
ISSN :1349-7235
Publisher :The Japanese Society of Internal Medicine
URI :http://hdl.handle.net/20.500.12000/47242
Citation :Internal Medicine Vol.46 no.7 p.359 -362
Appears in Collections:Peer-reviewed Journal Articles (Faculty of Medicine)

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