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Title :Diagnostic performance of serum interferon gamma, matrix metalloproteinases, and periostin measurements for pulmonary tuberculosis in Japanese patients with pneumonia
Authors :Yamauchi, Momoko
Kinjo, Takeshi
Parrott, Gretchen
Miyagi, Kazuya
Haranaga, Shusaku
Nakayama, Yuko
Chibana, Kenji
Fujita, Kaori
Nakamoto, Atsushi
Higa, Futoshi
Owan, Isoko
Yonemoto, Koji
Fujita, Jiro
Issue Date :9-Jul-2020
Abstract :Serum markers that differentiate between tuberculous and non-tuberculous pneumonia would be clinically useful. However, few serum markers have been investigated for their association with either disease. In this study, serum levels of interferon gamma (IFN-γ), matrix metalloproteinases 1 and 9 (MMP-1 and MMP-9, respectively), and periostin were compared between 40 pulmonary tuberculosis (PTB) and 28 non-tuberculous pneumonia (non-PTB) patients. Diagnostic performance was assessed by analysis of receiver-operating characteristic (ROC) curves and classification trees. Serum IFN-γ and MMP-1 levels were significantly higher and serum MMP-9 levels significantly lower in PTB than in non- PTB patients (p < 0.001, p = 0.002, p < 0.001, respectively). No significant difference was observed in serum periostin levels between groups. ROC curve analysis could not determine the appropriate cut-off value with high sensitivity and specificity; therefore, a classification tree method was applied. This method identified patients with limited infiltration into three groups with statistical significance (p = 0.01), and those with MMP-1 levels < 0.01 ng/ mL and periostin levels ≥ 118.8 ng/mL included only non-PTB patients (95% confidence interval 0.0–41.0). Patients with extensive infiltration were also divided into three groups with statistical significance (p < 0.001), and those with MMP-9 levels < 3.009 ng/mL included only PTB patients (95% confidence interval 76.8–100.0). In conclusion, the novel classification tree developed using MMP-1, MMP-9, and periostin data distinguished PTB from non- PTB patients. Further studies are needed to validate our cut-off values and the overall clinical usefulness of these markers.
URL :https://doi.org/10.1371/journal.pone.0227636
Type Local :雑誌掲載論文
ISSN :1932-6203
Publisher :Public Library of Science
URI :http://hdl.handle.net/20.500.12000/47365
Citation :PLoS ONE Vol.15 no.1
Appears in Collections:Peer-reviewed Journal Articles (Faculty of Medicine)

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