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Title :Stage-specific embryonic antigen-4 is a histological marker reflecting the malignant behavior of prostate cancer
Authors :Nakamura, Yuichiro
Miyata, Yasuyoshi
Matsuo, Tomohiro
Shida, Yohei
Hakariya, Tomoaki
Ohba, Kojiro
Taima, Takenobu
Ito, Akihiro
Suda, Tetsuji
Hakomori, Sen-itiroh
Saito, Seiichi
Sakai, Hideki
Issue Date :26-Jun-2019
Abstract :Stage-specific embryonic antigen-4 (SSEA-4), a specific marker for pluripotent stem cells, plays an important role in the malignant behavior of several cancers. Here, SSEA-4 expression was evaluated by immunohistochemistry using monoclonal antibody RM1 specific to SSEA-4 in 181 and 117 prostate cancer (PC) specimens obtained by biopsy and radical prostatectomy (RP), respectively. The relationships between SSEA-4 expression in cancer cells or the presence of SSEA-4-positive tumor-infiltrating immune cells (TICs) and clinicopathological parameters were analyzed. SSEA-4 expression in cancer cells was significantly associated with Gleason score, local progression, and lymph node and distant metastasis. In RP specimens, high SSEA-4 expression in cancer cells and the presence of SSEA-4-positive TICs were significant predictors of pT3, i.e., invasion and worse biochemical recurrence (BCR) after RP, respectively, in univariate analysis. In contrast, combination of high SSEA-4 expression in cancer cells and the presence of SSEA-4-positive TICs was an independent predictor for pT3 and BCR in multivariate analysis. Biologically this combination was also independently associated with suppression of apoptosis. Thus, the co-expression of SSEA-4 in cancer cells and TICs may have crucial roles in the malignant aggressiveness and prognosis of PC. Invasive potential and suppression of apoptosis may be linked to SSEA-4 expression.
URL :https://doi.org/10.1007/s10719-019-09882-2
Type Local :雑誌掲載論文
ISSN :1573-4986
Publisher :Springer Nature
URI :http://hdl.handle.net/20.500.12000/47508
Citation :Glycoconjugate Journal Vol.36 no.5 p.409 -418
Appears in Collections:Peer-reviewed Journal Articles (Faculty of Medicine)

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