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Title :IL13 genetic polymorphisms, smoking, and eczema in women : a case-control study in Japan
Authors :Miyake, Yoshihiro
Tanaka, Keiko
Arakawa, Masashi
Issue Date :21-Oct-2011
Abstract :Background: Several genetic association studies have examined the relationships between single nucleotidepolymorphisms (SNPs) in the IL13 gene and eczema, and have provided contradictory results. We investigated therelationship between the IL13 SNPs rs1800925 and rs20541 and the risk of eczema in Japanese young adultwomen.Methods: Included were 188 cases who met the criteria of the International Study of Asthma and Allergies inChildhood (ISAAC) for eczema. Control subjects were 1,082 women without eczema according to the ISAACcriteria, who had not been diagnosed with atopic eczema by a doctor and who had no current asthma as definedby the European Community Respiratory Health Survey criteria. Adjustment was made for age, region of residence,number of children, smoking, and education.Results: The minor TT genotype of SNP rs1800925 was significantly associated with an increased risk of eczema inthe co-dominant model: the adjusted odds ratio was 2.19 (95% confidence interval: 1.03-4.67). SNP rs20541 was notrelated to eczema. None of the haplotypes were significantly associated with eczema. Compared with women withthe CC or CT genotype of SNP rs1800925 who had never smoked, those with the TT genotype who had eversmoked had a 2.85-fold increased risk of eczema, though the adjusted odds ratio was not statistically significant,and neither multiplicative nor additive interaction was statistically significant.Conclusions: Our findings suggest that the IL13 SNP rs1800925 is significantly associated with eczema in Japaneseyoung adult women. We could not find evidence for an interaction between SNP rs1800925 and smoking withregard to eczema.
URL :https://doi.org/10.1186/1471-2350-12-142
Type Local :雑誌掲載論文
ISSN :1471-2350
Publisher :BioMed Central
URI :http://hdl.handle.net/20.500.12000/47766
Citation :BMC Medical Genetics Vol.12
Appears in Collections:Peer-reviewed Journal Articles (Faculty of Global and Regional Studies)

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